Causes of gastrointestinal perforation: 1, the most common cause is peptic ulcer, as the ulcer continues to progress, gradually penetrate the muscular layer, the plasma membrane layer, and finally penetrate the whole layer of the stomach, duodenal wall and lead to perforation. Gastrointestinal perforation has a lot to do with people’s bad dietary habits, such as overeating or satiating a meal and starving a meal, all of which are easy to cause peptic ulcers, which can lead to perforation; 2. Gastrointestinal tumor rupture can also cause perforation, such as gastrointestinal tumors. With the growth of the tumor, the central part of the tumor will be ischemia, necrosis, and finally cause the tumor to break, if it breaks outward, thus causing perforation; 3, inflammatory diseases of the intestinal tract, such as enteric typhoid fever, which will eventually lead to intestinal perforation; 4, trauma, if the abdomen is subjected to trauma, it will lead to perforation of the gastrointestinal tract.