Itchy soles at night may be caused by ringworm, mosquito bites, eczema and other diseases, need to clarify the cause of the corresponding treatment. 1. Tinea pedis: fungal infection caused by tinea pedis will cause the soles of the feet itchy at night, the patient will also have the soles of the feet skin keratinized scaly, dry cracks, can be used externally ketoconazole, terbinafine and other drugs for treatment. 2. Mosquito bites: Itchy soles at night may also be caused by mosquito bites, more common in summer, the patient will also have the soles of the feet of the wind, can be used locally soda, glycerol for treatment. 3. Eczema: sleep at night the soles of the feet itchy may also be caused by eczema, it will also have the soles of the feet of the rash, localized oozing, such patients should find out the causes of eczema and avoid scratching the skin to cause breakthroughs and infections. Sleeping on the soles of the feet itchy also related to other causes (such as hives), need to consult a doctor in a timely manner, clear cause of the disease in the physician’s guidance to carry out the appropriate treatment.