China is a large country of hepatitis B, and Guangdong Province is a large province of hepatitis B. There are many women of childbearing age who are carriers of hepatitis B virus, and these women face the problems of pregnancy, childbirth and breastfeeding, so what to pay attention to! 1, before pregnancy Before pregnancy must do pre-conception tests, check liver function, hepatitis B virus DNA quantification, AFP and do hepatobiliary ultrasound to see if the transaminases are normal, hepatitis B virus replication and liver lesions. If the transaminases are abnormal, especially if the viral replication is high at the same time, enzyme-lowering and antiviral treatment will be required. After treatment, the aminotransferase will be normalized and pregnancy will be considered only after the infection doctor decides whether it is suitable for pregnancy. 2. Pregnancy Early in pregnancy, if hepatitis B major triplet activity (elevated transaminases) is found to be prone to miscarriage, or continuing pregnancy will increase the burden on the liver, termination of pregnancy may be recommended. In addition to routine prenatal checkups after mid-pregnancy, liver function should be reviewed regularly, especially for pregnant women with major triple-positive hepatitis B. Liver function and hepatitis B virus DNA should be checked once a month, and if transaminases are abnormal, hospitalization is required for enzyme-lowering liver protection treatment. From 26-28 weeks of gestation, if the transaminases are normal but the viral DNA quantification is above the sixth power of 10, oral antiviral therapy can be administered under the guidance of a specialist. Pregnant women with only positive surface antigen or small triplets can have their transaminases and viral DNA quantified as long as they are rechecked regularly. 3. Labor and delivery Hepatitis B virus carriage is not an indication for cesarean delivery. Generally speaking, as long as the vaginal delivery does not last long, the chance of mother-to-child hepatitis B transmission is similar to that of cesarean delivery. If you are hepatitis B triple positive and have elevated transaminases, you need to use a vitamin K1 during delivery to prevent postpartum hemorrhage. The blood of the umbilical cord is drawn during delivery to test the hepatitis B two to one half and hepatitis B virus DNA quantification, to see if the intrauterine hepatitis B virus has been infected. 4.Postpartum Within 6-12 hours after birth, the baby should receive 200u of hepatitis B immunoglobulin and 10ug of hepatitis B vaccine to achieve the dual protection of active and passive immunity. After delivery, you can breastfeed and do not need to test the DNA quantification of hepatitis B virus in breast milk. If you have taken antiviral medication during pregnancy, you will need to continue taking oral antiviral medication for one month after delivery, during which time you cannot breastfeed. The baby will need to be vaccinated with 10ug of hepatitis B vaccine at full term and 6 months of age. one month after all hepatitis B vaccinations are completed, the child’s blood will be drawn for hepatitis B hemoglobin and hepatitis B virus DNA. care should be taken in future daily contact not to allow open wounds to come into contact with the child, and not to kiss the child if there is an ulcer in the mouth to avoid transmission to the baby via blood sources.