Coronary heart disease is most common in middle-aged people and above, mostly in men after 45 years old, the age of onset in women is about 10 years later than that of men, mostly after menopause, but a very small number of children can also suffer from coronary heart disease. Coronary heart disease is one of the cardiovascular diseases, a very small number of children for some reason will suffer from this disease, we should come together to understand the following three categories of children susceptible to coronary heart disease, do a good job of prevention in advance, will be strangled in the cradle of the disease. 1, familial hypercholesterolemia It is well known that increased blood cholesterol levels are an important independent risk factor for coronary heart disease. Familial hypercholesterolemia is rare, with about 1 case per 1 million people. Patients may be born with blood cholesterol levels as high as 700-1200 mg/dl, up to 4-7 times the normal level. Typical anginal symptoms are most often seen before the age of 20, all with early onset atherosclerosis, and cases of myocardial infarction before the age of 2 have been reported. Clinical features include yellow tumors of the skin, yellow tumors of the tendons and corneal rings (translucent gray-white rings in the peripheral part of the cornea) and severe and diffuse atherosclerosis of the whole body. 2, congenital coronary artery malformation Abnormal pulmonary artery origin of the coronary artery. Normal coronary arteries originate from the aortic root. In approximately 0.4% of all patients with prophetic heart disease, the coronary arteries originate from the pulmonary artery. The most common clinical presentation is myocardial infarction and heart failure in infancy, usually with onset 2 to 4 months after birth, with angina-like symptoms that can be easily mistaken for infantile gastrointestinal colic, dyspnea during breastfeeding and defecation, irritability, crying, pallor, profuse sweating, and occasionally loss of consciousness. Congenital coronary artery venous fistula can also appear angina symptoms. 3, rheumatic fever and other systemic diseases and inflammation of the coronary arteries may be involved in adolescents, resulting in coronary heart disease. Some children and adolescents are exposed to cigarettes at a very early age and become smokers, and the harmful substances contained in cigarettes can damage the heart little by little. This bad habit brings serious harm and influence to patients, so we must pay attention to it.