Is chemotherapy necessary for recurrence of pancreatic cancer after surgery? Pancreatic cancer is a serious disease and metastasis may occur. Don’t think that the disease has been cured after pancreatic cancer surgery, but it is still necessary to carry out postoperative observation to find out the abnormality in time and carry out treatments, such as: chemotherapy. So, is chemotherapy necessary for recurrence of pancreatic cancer after surgery? The answer is no. The treatment plan for postoperative recurrence of pancreatic cancer should be based on the situation of surgical resection of the patient and the patient’s physical condition. Early stage pancreatic cancer has a high rate of complete surgical resection, and the problems that should be targeted after surgery are the damage caused by surgery to the immune system, prevention of recurrence, and suppression of hidden cancer cells. To address such issues, chemotherapy is not applicable because it acts directly on the cancer cells that have already formed and is not suitable for patients with compromised immune systems due to its toxicity. After surgery for early stage pancreatic cancer, post-surgery treatment is mainly encouraged to be the conditioning treatment of traditional Chinese medicine, because traditional Chinese medicine can improve the immune function of patients on one hand, and inhibit the hidden cancer cells on the other hand, which can prevent recurrence. Surgery for middle and late stage cardia cancer is mostly palliative local excision, and chemotherapy is a more effective treatment for postoperative recurrence, and combination chemotherapy is slightly more effective than single-drug chemotherapy. However, chemotherapy is more toxic, and patients will have a series of toxic side effects after treatment, and it also damages the immune system of human body, which makes many patients extremely weak and unable to continue treatment after several courses of chemotherapy. Therefore, chemotherapy should be accompanied by traditional Chinese medicine treatment, which on one hand can reduce the toxicity of chemotherapy and improve the symptoms, and on the other hand can synergistically inhibit the cancer and play the role of healing effect, and on the other hand, traditional Chinese medicine can improve the immune function of the patients, so that the treatment can be carried out smoothly. For middle and advanced pancreatic cancer patients who are physically weak and have difficulty in tolerating chemotherapy after surgery, they can be treated with Chinese medicine alone, which is surely effective in improving symptoms and quality of life.