The side effects of amitriptyline are mainly manifested as anticholinergic reaction in the early stage, and may appear in the later stage of the central nervous system adverse reaction, as well as bone marrow suppression, toxic liver damage and so on, in the case of standardized use of the drug, generally does not appear to be outrageous. Amitriptyline belongs to the tricyclic antidepressant drugs, in the clinic is mainly used for the treatment of anxiety disorders or motorized depression, the side effects of the drug are mainly manifested in the following aspects: 1. The early stage of treatment shows anticholinergic reactions such as excessive sweating, dry mouth, urinary difficulties, blurred vision and constipation. 2. In the later stages of treatment, central nervous system adverse reactions such as drowsiness, dizziness and tremor may occur. 3. Some patients may also experience postural hypotension, seizure-induced seizures, bone marrow suppression and toxic liver damage. Contraindications to amitriptyline include patients with severe heart disease, epilepsy, hepatic impairment, glaucoma, and urinary retention. Prudent use of amitriptyline: prostate hypertrophy, the elderly, patients with hepatic and renal insufficiency, patients with cardiovascular disease and so on. In order to ensure the safety and effectiveness of the medication, it is important to follow the doctor’s instructions strictly.