Roughness of the common bile duct is an imaging manifestation that can be caused by a variety of reasons, commonly stones, inflammation, and bile duct tumors. 1. Inflammation: The normal inner wall of the bile duct is smooth. When inflammation occurs in the bile ducts, the cells of the bile duct wall proliferate, thus making the wall uneven and rough. Common diseases include cholecystitis and cholangitis. 2. Stones: When stones occur inside the common bile duct or when gallbladder stones fall into the common bile duct, the common bile duct can be seen to be uneven and rough on imaging. In addition, stones in the bile duct can also lead to certain inflammation, which can also make the duct rough. 3. Tumor: The bile duct wall has produced a tumor, and the tumor mass will also make the bile duct wall become uneven and rough. For patients with rough bile duct wall, they should go to the relevant departments of regular hospitals as soon as possible, and the physicians will make comprehensive diagnosis and give corresponding treatment according to the examination results and specific conditions of the patients; the patients should not carry out self-diagnosis with the checklist.