Pancreatic metastasis of lung cancer can be treated with optimal supportive therapy, chemotherapy, radiotherapy and targeted therapy. 1. Optimal supportive treatment: patients with pancreatic metastasis of lung cancer belong to patients with advanced stage of tumor, and at this stage, they often have manifestations of emaciation, anemia and cachexia, etc. They should pay attention to strengthening nutrition, consuming more food rich in high protein, and at the same time, pay attention to a balanced and light diet, and take appropriate activities to strengthen the resistance of the organism. 2. Chemotherapy: patients with pancreatic metastasis of lung cancer can be treated with chemotherapeutic drugs such as cisplatin, carboplatin, gemcitabine, vincristine and so on, which can alleviate the symptoms of patients and prolong their survival period. 3. Radiotherapy: pancreatic metastasis of lung cancer can be treated with external irradiation of pancreatic metastases, and local radiotherapy can help to reduce the size of metastases and alleviate patients’ symptoms. 4. Targeted therapy: Targeted therapy is especially suitable for patients with advanced lung cancer, and the use of targeted drugs against target genes can often significantly prolong the survival of patients, and the targeted drugs include erlotinib, gefitinib and so on. Patients with pancreatic metastasis of lung cancer should go to the hospital in time, set up confidence in the treatment of the disease, and carry out standardized treatment under the doctor’s advice, which is expected to alleviate the pain of the patients and prolong the survival period.