The treatment of bipolar disorder is not simply a prescription, but is based on a horizontal (current clinical status) and vertical (severity, frequency, consequences of past episodes) assessment of the bipolar patient, and the results of the assessment are used as a basis to discuss with the patient’s family the treatment plan and treatment settings. The following treatment principles should be followed in the selection of treatment plan and treatment setting: 1. Integrated treatment principle: Treatment of bipolar disorder should be a combination of pharmacotherapy, physical therapy, psychotherapy and other measures to improve the efficacy, improve compliance, prevent relapse and reduce the risk of white-kill, improve social functioning and improve quality of life. 2, long-term treatment principles: bipolar disorder is a recurrent cycle of episodic course, the treatment of the same standard in addition to alleviate the symptoms of the acute phase, should adhere to the principles of long-term treatment to interrupt the cycle of recurrent episodes. Long-term treatment can be divided into three treatment periods: (1) acute treatment period: the purpose is to control the symptoms, shorten the course of the disease. In general, 6-8 weeks can be achieved. (2) Consolidation treatment period: After the acute symptoms are completely relieved, we will enter into the consolidation treatment to prevent the symptoms from reigniting and to promote the recovery of social functions. The general consolidation treatment time is 4-6 months for depressive episodes and 2-3 months for manic or mixed episodes. (3) Maintenance treatment period: the foot of the day to prevent relapse, maintain good social function and improve the patient’s quality of life, maintenance treatment should last for how long there is no definite, such as the past for multiple episodes, can maintain treatment for 2-3 years or longer. 3, patients and family members to participate in treatment principles: should be established and maintained with patients and family members treatment alliance. Conduct relevant health education and psychosocial ten pre. The content can include the nature of the disease of bipolar disorder, clinical manifestations, characteristics of the disease course, treatment methods and knowledge of relevant drugs, the need for long-term treatment, early manifestations of relapse and self-monitoring, relapse-related factors and treatment, marriage and genetic predisposition to the disease and other issues. This will help improve the doctor-patient relationship, improve patient compliance with treatment, enhance the effect of relapse prevention, and improve the quality of life of patients. 4, to ensure the safety of the principles of treatment sites: Treatment sites should ensure the effective implementation of treatment, the protection of patients and the safety of others. The following conditions should be hospitalized: acute and severe patients, patients who refuse to eat, self-injury or suicide or have the tendency to injure others, poor compliance, inability to control their behavior, harassment of society and family, lack of effective guardians, with obvious psychiatric symptoms, with important organ disease or substance dependence and alcohol dependence requiring simultaneous treatment, the elderly, pregnant women and frail people who need close supervision. (1) First-line medication for manic episodes and mixed episodes: lithium salt combined with antipsychotics or valproate combined with antipsychotics. Short-term use of benzodiazepines also helps to treat mixed episodes valproate seems to be better than lithium? Antipsychotics as before recommend 2nd generation antipsychotics as the mainstay, with more evidence of effectiveness for olanzapine and risperidone. (2) First-line pharmacotherapy for bipolar depression: lithium salts or lamotrigine are the mainstay. Antidepressants alone are not recommended (unless depressive symptoms are particularly severe a mood stabilizer combined with an antidepressant can be considered, but evidence-based evidence is very limited). Electroconvulsive therapy may be considered for mizu-phase depression with severe suicidal or psychotic symptoms. (3) Rapid cycling type: Determine the presence of factors that exacerbate rapid cycling, such as hypothyroidism and alcohol abuse, and treat these factors. Antidepressants also aggravate the cycle and cannot be used. The basic treatment medication is a mood stabilizer such as valproate or lithium, and in most cases a combination of 2nd generation antipsychotics or lamotrigine is required. When combining Kaw drugs, it is important to understand the drug interactions arising from the induction or inhibition of metabolic enzymes by the drugs.