In modern society, more and more people are suffering from Meijer’s syndrome. Because of the similarity between the symptoms of Meijer’s syndrome and some other facial diseases, it causes not enough attention in the early onset of Meijer’s syndrome, and most people in the face of Meijer’s syndrome do not know what symptoms the disease has, and it is easy to be confused with other diseases, thus delaying the disease. A. What are the diseases that Meijer’s syndrome is easily confused with? 1, dry eye: symptoms include dry eyes, eye fatigue, eye itching, foreign body sensation, burning sensation, sticky secretions, fear of wind, photophobia, sensitivity to external stimuli, but does not manifest as eye dystonia. 2, trigeminal neuralgia: trigeminal neuralgia is a kind of facial paroxysmal transient severe pain, the pain can be accompanied by facial muscle twitching when severe. In severe cases of Meijer’s syndrome, facial pain symptoms may also occur, but the pain is not as intense as trigeminal neuralgia. 3, brucellosis syndrome: brucellosis syndrome has symptoms of open mouth, paroxysmal deep and rapid breathing in the interval between episodes of dystonia, accompanied by nystagmus, and its pathogenesis is localized in the thalamus. 4. myasthenia gravis: both Major’s syndrome and myasthenia gravis have symptoms of difficulty in opening the eyes, but the latter is an abnormal muscle strength of the levator muscle, often with morning lightness and evening heaviness, while the former is a paroxysmal contracture or tonic contraction of the orbicularis oculi muscle resulting in eyelid closure. How to determine Major’s syndrome? 1. Bilateral blepharospasm: The most common first symptom in patients is frequent blinking in both eyes, accounting for about 76% to 77% of cases, and some of them start with one eye and gradually develop in both eyes. Blepharospasm is often preceded by eyelid irritation, dry eyes, photophobia, and increased transients. The frequency of blepharospasm often ranges from sparse to frequent. The spasms can last from a few seconds to 20 minutes and can continue to contract without treatment resulting in functional “blindness”. Patients often need to use their hands to pull both upper lids up to see the road and are afraid to go out alone or cross the street. 2. Mandibular dystonia: Patients only have spasticity of the muscles of the mouth, lips and jaw. 3, mouth and jaw and tongue spasm: often manifested as open mouth, teeth clenching, shrinking lips pout, tongue extension, etc., resulting in odd and special facial expression. Severe cases can cause dislocation of the jaw, tooth wear, can affect the vocalization and swallowing, mouth and jaw spasms are often triggered by speech chewing. In addition to eyelid spasm and abnormal muscle tone of the mouth and jaw, Meijer syndrome can also be accompanied by oblique neck head backward and forward flexion. The current treatment for Meijer syndrome is mainly pharmacological, botulinum toxin local injection and surgical treatment. The internationally recognized method for the surgical treatment of Meijer syndrome is deep brain electrical stimulation, commonly known as “brain pacemaker” surgery, which has the characteristics of small trauma, fast recovery, no damage to the normal structure of the brain, reversible, adjustable, personalized, etc. It is an effective treatment with relatively safe and less side effects.