Folic acid metabolism generally refers to folate metabolism gene test, folic acid assay and folate metabolism gene test are two completely different tests, folic acid assay generally refers to check the level of folate in serum, while folate metabolism gene test is to determine whether the body lacks genes involved in folate metabolism.1. Folic acid assay: It is mainly to determine whether the body is deficient in folate, by drawing blood to directly detect the level of folate in serum, to determine Folic acid level is normal or not, and whether folic acid supplementation is needed. Folic acid measurement can only determine the current level of folic acid, but not the metabolic ability of folic acid and the genes involved in folic acid metabolism. 2. Folic acid metabolism testing: mainly through genetic testing, we can determine whether there are problems with genes related to folic acid metabolism, some genes can promote folic acid metabolism, while some genes can inhibit folic acid metabolism. According to different genes, the ability of folic acid metabolism can be determined, which in turn can help determine the daily dose of folic acid. If the ability to metabolize folic acid is poor, folic acid supplementation is recommended during non-pregnancy, and the use of folic acid tablets needs to be increased during pregnancy in addition to the regular dosage. Folic acid should be taken during the first 3 months of pregnancy and the second 3 months of pregnancy to reduce the probability of folic acid deficiency causing malformations in fetal neural tube development. However, it should be taken according to medical advice and should not be used blindly on your own to avoid other adverse reactions.