White spots on the face of children are commonly associated with the following diseases, including vitiligo, pityriasis albuginea, lichen planus, anaplastic nevus and anemic nevus. Vitiligo manifests as complete pigment loss spots, porcelain white or milky white, with clear borders, smooth surface and no self-perceived symptoms. The onset of vitiligo is related to genetics, autoimmunity, micronutrient copper deficiency and melanocyte self-destruction. Pityriasis albuginea manifests as round or oval hypopigmented spots on the face with unclear borders, which can have fine scales, mostly caused by excessive sun exposure or vitamin deficiency, and is self-limiting. Pemphigus foliaceus is a fungal infection that causes hypopigmented spots between the eyebrows and on the forehead of children. Pigmented nevi and anemic nevi often develop at birth or shortly after birth and have no effect on health, and the white spots often do not recover on their own.