Retroperitoneal lymph node enlargement should first be examined and diagnosed clearly, and then treated according to the cause of the disease. Clinically, inflammation of the abdominal cavity and retroperitoneal organs, malignant tumors and other diseases may cause retroperitoneal lymph node enlargement, and the specific treatment will be selected according to the original disease. 1. Inflammation: clinically, inflammatory infections of the liver and biliary system, colon, small intestine, stomach, pancreas, kidneys and other organs, peritonitis and other lesions may lead to retroperitoneal lymph node enlargement. After clear diagnosis, intravenous infusion of ceftriaxone sodium, levofloxacin, ornidazole and other antibiotic treatment is needed to control and eliminate the infection, and surgical treatment can be given if necessary. 2. Malignant tumors: abdominal and retroperitoneal malignant tumors, such as gastric cancer, colon cancer, liver cancer, gallbladder cancer, pancreatic cancer, renal cancer, abdominal malignant lymphoma and so on, can also lead to retroperitoneal lymph node enlargement, which can be treated by surgery, radiotherapy and other methods. Specific treatments and medications need to be carried out under the guidance of doctors.