Mecobalamin and amoxicillin are usually taken together. Whether or not to take these 2 drugs at the same time mainly depends on whether the condition requires it. Methylcobalamin tablets are generally used in the treatment of peripheral neuropathies, such as facial neuritis, Guillain-Barre syndrome, diabetic peripheral neuropathy, etc., and usually need to be taken for a long time. Methylcobalamin has some side effects, can be seen in loss of appetite, nausea, vomiting and other gastrointestinal adverse reactions, rare rash, urticaria and other allergic reactions. Rash and other allergic reactions should be discontinued on medical advice. Amoxicillin is a commonly used penicillin antibiotic, for bacterial infections caused by upper respiratory tract infections, pharyngitis, skin ulcerations and infections, have a better effect. Patients with a history of penicillin allergy should not take these drugs. These two drugs can be taken at the same time, the clinical should follow the doctor’s advice according to the needs of the condition to decide whether to take these two drugs at the same time, the patient should go to the hospital after consultation, by the doctor according to the condition to guide the use of medication.