When taking targeted drugs with blurred eyes, you need to consider discontinuing the targeted drug that caused the adverse reaction, and you need to follow the doctor’s prescription for topical treatment in the eyes. Most of the targeted drugs belong to the epidermal growth factor receptor inhibitors and protein kinase inhibitors, such as cetuximab, imatinib, etc. Targeted drug treatment can lead to a lot of ocular adverse reactions, such as tearing, photophobia, blurred vision and other inflammatory manifestations of the ocular surface. Discontinuation of the drug or switching to other targeted drug therapy can be considered on medical advice if necessary. When ocular surface inflammation occurs, epidermal growth factor eye drops, artificial tears, low concentration glucocorticoid eye drops, antibiotic eye drops can be used under the guidance of the doctor to alleviate the blurred vision caused by conjunctivitis, keratitis and other ocular surface irritation, and corneal bandage lenses can also be worn to alleviate the corneal discomfort reaction. In conclusion, the treatment process of targeted drugs can occur in the eye adverse reactions, need to be based on specific circumstances, in accordance with the doctor’s instructions for the appropriate treatment, targeted drugs need to be discontinued in the relevant departments under the guidance of the guidance of doctors and monitoring.