At present, as it is the onset season of HFMD, some of the HFMD cases have serious complications leading to the death of the children, causing some parents to panic about the disease, and as long as the rash appears, they think it is HFMD and blindly seek medical attention, causing a psychological burden. According to my personal clinical experience, the rash characteristics of HFMD are introduced to the general public so that they can be distinguished from the rashes produced by other diseases. HFMD is an infectious disease caused by an enterovirus, with an incubation period of generally 3-7 days and no obvious prodromal symptoms: most patients have a sudden onset of disease. The rash mainly invades four parts of the body: hands, feet, mouth and buttocks; clinically, it has more four characteristics of no pain, no itching, no crusting and no scarring. Initially, there may be mild upper sensory symptoms. Due to painful oral ulcers, the child salivates and refuses to eat. Oral mucosal rash appears relatively early, initially as corn-like papules or blisters surrounded by a red halo, mainly on the tongue and both cheeks, and often on the lateral side of the lips and teeth. The rash is not itchy, and the papules turn from red to dark in about 5 days and then fade; the herpes is round or oval and flat, with cloudy liquid inside, with a long diameter in line with the direction of the skin, such as the size of a soybean, generally without pain and itchiness, and leaves no trace after healing. Hand, foot and mouth lesions may not all appear in the same patient. Blisters and rashes are usually distinguished from eczema, dermatitis, and allergic rashes within a week of recognizing U fermium, and generally these rashes are more pruritic and painful.