Principles of medication during breastfeeding 1, for the health of the baby, it is best not to use drugs during lactation. In particular, the drugs that are contraindicated and prudent to use during breastfeeding, Xiong Zhiyan of the Department of Anus and Intestines of the Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine 2, if you need to use drugs, you must determine the indications of lactating mothers to dump the drugs and choose the drugs that have good therapeutic efficacy. 3, choose to enter the amount of milk is small, the newborn baby has little effect on the drug. 4, the route of administration of oral or local best, half-life needs to be short , to avoid sustained release . Reduce the peak level in plasma. Thus reducing the infant’s absorption. 5, to pay attention to master the time of the drug. It is best to take the drug after breastfeeding or breastfeeding immediately after taking the drug, and as far as possible to delay the next breastfeeding time, preferably at an interval of more than 4h, in order to avoid or reduce the infant to take the drug through the breast milk. 6, in the application of the drug dose is too or the efficacy of a long time, should be detected in the baby’s blood concentration. 7, if the mother has a disease must be used, and can not be confirmed that the drug is safe for infants, can suspend breastfeeding, switch to pumping breast milk, so that it can continue to breastfeed after stopping the drug. 8, pay attention to individual differences in infants. Some idiosyncratic body such as lack of glucose 6 a phosphate dehydrogenase (G a 6 a PD) of infants resistant to some oxidizing drugs can cause hemolysis, gangrene and so on. The first consideration should be the necessity of the drug for the breastfeeding woman. If there is no evidence that the benefits of the drug outweigh the risks, the drug should be avoided as much as possible; when symptoms can be tolerated, allopathic treatment should be used, avoiding symptomatic drugs; and systemic administration should be avoided if it is possible to administer the drug locally. If the drug must be used, it should be chosen for its high molecular mass, low lipid solubility, short half-life, low lactate-to-blood ratio, and low pKa value. For example, for the treatment of infections in lactating women, choose antimicrobial drugs of the 8-lactam class with short half-lives and avoid macrolides with long half-lives. For drugs with less conclusive evidence-based medical evidence, clinical selection should be avoided as much as possible. Dosing time The concentration of drugs in breast milk fluctuates greatly with blood concentration, so the choice of dosing time is very important for the safe use of drugs during lactation. If the drug is taken immediately after breastfeeding, it will ensure that the blood concentration has been minimized by the time of the next breastfeeding. If the drug is taken orally, the effect of food on the absorption of the drug should also be considered, so the mother should choose the fastest way of absorption of the drug, such as general drugs should be taken on an empty stomach, while the fat-soluble drugs will be taken at the time of eating. The selective use of drugs for lactating women 1, antibacterial drugs: lactating women applying metronidazole, tinidazole will cause headache, insomnia or limb numbness in infants. Isoniazid can cause central excitation in breastfeeding infants. Sulfonamides can make infants nausea, vomiting, leukocytes and thrombocytopenia: penicillin will make infants have serious allergic reactions, benzylpenicillin can cause infant diarrhea or Candida infections, macrolides, aminoglycosides, tetracyclines, jellies, cyanocitric acid, etc. should not be applied. 2, sedative sleeping drugs: lactating women use such drugs, not only will the baby is asleep, but also can cause Jaundice in newborns. 3, anti-rheumatism, painkillers: Pau-Texon is very easy to make the breastfeeding child form specific allergies, anti-inflammatory pain can make the breastfeeding child spasm. Morphine analgesics can easily cause respiratory depression. 4, antispasmodic, asthma drugs: lactating women should use atropine, milk secretion will be reduced, and can make the baby appear high fever, dry skin, dilated pupils, restlessness and a series of atropine poisoning symptoms. Aminoglutethimide can make babies excited, restless, nausea and vomiting when used by lactating women. 5, antihypertensive, hypoglycemic drugs: lactating women applying reserpine can cause nasal congestion, purple lips, loss of appetite, diarrhea and so on. Taking D8 can cause hypoglycemia in infants. 6, antiarrhythmic drugs: Xindean, Xindeeping, Xindenin, Xinde Jing, often crocodile, etc., after the use of lactating women, can be through the breast milk. Accumulation in the baby’s body, resulting in slow pulse, tracheal spasm, hypoglycemia and other reactions. 7, taking contraceptives during breastfeeding, will make the male breast zygoma become larger, female infants vaginal epithelial hyperplasia; antiepileptic drugs will make the baby cyanosis, methemoglobinemia, the whole body is a large petechiae, miso sleep, defecation. Anti-cancer drugs, its toxic side effects are greater, in the use of anti-cancer drugs period, should stop breastfeeding. Quinidine, isoniazid, aspirin, furosemide can make the congenital lack of glucose 6-phosphate dehydrogenase in infants with acute hemolytic anemia, serious cases can be life-threatening, so do not use. Nursing women use the drug, can be through the milk, the adverse effects of the drug will first be reflected in the baby.