Early breast cancer ki67 positive rate of 20% is not serious, generally can not be generalized, specific according to the individual situation to judge. ki67 index itself is only a reference, the most important reason affecting the prognosis of the patient’s tumor is the tumor stage and grade. ki67 reflects the tumor cell proliferation index, which indicates the degree of active cell proliferation. Ki67 reflects the index of tumor cell proliferation, which indicates the degree of active cell proliferation; the higher the Ki67 positive rate, the more rapid the cell proliferation, which usually indicates the higher degree of malignancy of the cells. Under normal circumstances, a Ki67 positive rate of 30%-40% or more is considered a more malignant tumor. If Ki67 is <15%, the tumor is usually considered to be low malignancy. Ki67 index itself only provides an auxiliary prediction or judgment basis, and its direct influence on the patient's prognosis is not sufficient, so it is still necessary to make a comprehensive judgment based on the patient's overall tumor condition. For example, whether the tumor is locally early or locally advanced and whether metastasis has occurred. Different tumor stages have different prognostic impacts. In addition, according to the tumor grading, it is also necessary to judge whether the degree of malignancy of the tumor is high or low, coupled with the degree of differentiation of the tumor cells, to comprehensively assess and judge the prognosis of the tumor. It is recommended that patients should seek medical treatment in time when the condition of breast cancer appears in early stage, and carry out appropriate treatment under the guidance of doctors to prevent the condition from worsening.