Most patients with diffuse brain injury are less likely to be awake, and the brain nerve cell damage is irreversible. Some patients may also recover if given timely and correct treatment early. Diffuse brain injury can occur in patients with a variety of diseases, such as severe craniocerebral trauma, and if the patient has severe ischemia in the brain, it may cause ischemic brain tissue necrosis and softening. If the patient has a large amount of cerebral hemorrhage can also occur, for different causes, the main thing is to carry out the appropriate etiological treatment, and at the same time to apply neuroprotective drugs, commonly used drugs Olacitant, Piracetam and Cytarabine. If the patient has severe brain injury causing hypoxemia, oxygen therapy should be given if necessary, and oxygen should be administered by mask or nasal cannula with low flow.