Glioma is a kind of brain tumor, mostly benign tumor. Diffuse glioma may appear on imaging, especially on magnetic resonance, as round or round-like low-density foci in the cortex or white matter, with some mixed density or high-density shadow in the middle. If the glioma is functional or diffuse, it may cause dysfunction of the contralateral limb and in some cases, seizures or persistent epilepsy. Diffuse glioma may cause intracranial edema, headache, nausea and vomiting if some tumors are large and diffuse. If there are obvious symptoms of neurological deficits or seizures, or if the glioma belongs to the functional area of the brain, the treatment is mainly gamma knife or surgical treatment. The next step of treatment for diffuse glioma depends on the clinical symptoms and size of the tumor.