The main symptoms of diffuse lymphoma stage IV are as follows, whether diffuse lymphoma involves liver, lung, bone, bone marrow and other organs. If these important organs are involved, then it is diffuse lymphoma stage IV. If the lung is involved, the main reason is the difficulty in breathing, chest mass, and pleural effusion. And if it appears to involve the liver, it is mainly multiple masses in the liver, causing decreased liver function, jaundice, ascites, decreased albumin, etc. And if the bone marrow is involved, then it can cause clinical manifestations such as whole blood cytopenia and bone pain. Therefore, the symptoms of diffuse lymphoma stage IV depend on the site of involvement.