Rigolenide tablets and acarbose are common hypoglycemic drugs, the effect of medication varies from person to person, it is impossible to compare which drug is better, the specific use of medication in accordance with the doctor’s instructions. Rigolenide tablets are short-acting insulin secretagogues, suitable for patients with type 2 diabetes whose high blood sugar cannot be effectively controlled by diet control, weight loss and exercise. The most common adverse effects of the drug are hypoglycemia and so on. Contraindications include known hypersensitivity to the product, patients with type 1 diabetes mellitus, C-peptide negative diabetes mellitus, diabetic ketoacidosis with or without coma, severe hepatic dysfunction, and current use of gemfibrozil. Acarbose can be used in conjunction with dietary control to lower postprandial blood glucose in people with type 2 diabetes and impaired glucose tolerance. Common adverse reactions to the drug include flatulence, diarrhea, and abdominal pain. The drug should be prohibited for use in people who are allergic to the product, people with chronic gastrointestinal dysfunction with significant digestive and absorption disorders, people suffering from disorders that may be worsened by intestinal flatulence, people with severe hepatic and renal impairments, people with diabetic ketoacidosis, pregnant and breastfeeding women. Reglanate tablets and acarbose can be used to lower blood sugar, the therapeutic effect of the two can not be compared, mainly because of the individual variability of the drug users, resulting in different effects of the drug for each person. People who meet the indications for the use of medication should choose the appropriate medication according to their own situation under the guidance of a physician. The specific use of drugs should be carried out under the guidance of specialists, not unauthorized use of drugs.