At present, there are many reasons for cranial defects in life. Due to the lack of cranial protection, the dura mater is in direct contact with the skin and so on, resulting in local collapse or bulge, which is easy to be squeezed, collision and so on causing cranial injury, which brings inconvenience to the work and life of patients. Therefore, when patients have cranial injury, they should do cranial repair surgery as soon as possible. There are two main purposes of skull repair surgery for skull defects, one is for safety and the other is for aesthetics. The choice of repair material for doing cranial bone repair surgery is also crucial. If the patient chooses a repair material that is not ideal, it may produce rejection or post-operative infection, resulting in the patient’s removal of the repair material and failure of the surgery. The time to do cranial repair surgery for cranial defects is recommended to perform cranial repair in one week for patients with relatively clean open cranial comminuted fractures without cranial hypertension. For patients with severe closed craniocerebral trauma and giant cranial defects caused by decompression of large bone flaps performed for cranial hypertension, cranial repair should be performed three months after the defect. At present, a few regular hospitals have selected the new PEEK material as the cranial repair material. PEEK material for cranial repair is superior to traditional repair materials, and the preoperative is based on the patient’s cranial defect morphology through 3D printing, and the appearance is no different from before. Cranial bone repair using PEEK as a repair material, through clinical practice found that PEEK material low density, insensitive to temperature, has high tissue stability, so that it can be sterilized under high temperature or radiation without deformation. And through a large number of clinical feedback found that PEEK material has ray permeability and will not have an impact on CT and MRI results, the current cranial repair material used in some places is titanium mesh. In fact, in addition to titanium mesh, there is now a more ideal and suitable material for cranial repair. This material is polyether ether ketone PEEK material cranial repair surgery, this surgery not only to achieve a single cranial repair, but also in the appearance of the plastic enough efforts, for each patient’s specific condition signs and so on scientific analysis and research, repair materials to optimize the design, develop a personalized and thoughtful cranial repair and appearance of the plastic program, and finally achieve beautiful appearance, anatomical integrity and functional perfect The unity is achieved by the aesthetic appearance, anatomical integrity and functional perfection.