Grey-Turner’s sign is a clinical sign that occurs in severe necrotizing pancreatitis when the pancreatic tissue is digested and absorbed by the pancreatic enzymes of the pancreas itself, resulting in a large release of pancreatic enzymes into the blood and some into the abdominal cavity, leading to localized subcutaneous bruising, commonly occurring in the left and right rib areas of the abdomen, clinically known as Grey-Turner’s sign. This condition is an important clinical sign of severe necrotizing pancreatitis. Generally, the prognosis is relatively poor in most cases, and some may develop multiple organ failure, such as renal failure, oliguria or liver failure, and some severe cases may easily develop life-threatening conditions, requiring active lavage, dialysis and electrolyte supplementation to maintain vital signs and symptomatic treatment.