Interleukin 8, or interleukin-8, checks the body for the presence of inflammation. Normal values for interleukin 8 range from 8.1 to 21.3 μg/L. Interleukin-8 is mainly produced by macrophages and is capable of transmitting immune messages. Interleukin 8 is elevated in inflammatory diseases. For example, glomerulonephritis, periodontitis, immune vasculitis, and enteritis can cause elevation. Interleukins can activate regulatory immune cells when inflammatory foreign bodies are present. Neutrophils react with interleukin-8 to produce active products. This leads to the appearance of localized inflammation for bactericidal purposes. The primary biological activity of interleukin-8 is to attract and activate neutrophils. Other tests should be performed when interleukin-8 is elevated. Such as routine blood, liver function, and urine routine in order to clarify the cause and treatment.