Grade III of lgA nephropathy does not mean renal insufficiency, mainly refers to the pathological grading of IgA nephropathy, and does not refer to the renal failure stage. Early clinical manifestations of lgA nephropathy are hematuria, proteinuria, edema, hypertension, etc. Most of the patients do not have renal function damage. If the disease is not treated actively and effectively, and delayed, resulting in renal function damage, renal insufficiency may eventually occur. Currently, Lee’s and Hass’ grades are commonly used to classify IgA nephropathy. lgA nephropathy grade III indicates that the lesion is more serious, usually diffuse thylakoid hyperplasia can occur, and crescents can be found in pathological tests, and at this time, it is necessary to use glucocorticosteroid drugs, such as methylprednisolone, etc. and immunosuppressant drugs, such as cyclophosphamide, etc., to carry on the treatment. It is recommended that patients with IgA nephropathy should consult the nephrology department of regular hospitals in time and follow the doctor’s instructions for standardized diagnosis and treatment.