Some studies have shown that long-term estrogen use can increase the risk of cardiovascular disease and breast cancer in women. There are a number of women who have become overly superstitious about estrogen therapy, resulting in abuse that has led to other diseases. These examples have caused some women to have a fear of estrogen instead. Experts point out that estrogen does provide good relief for menopausal syndrome, and as long as it is used in compliance with medical advice and not abused, it should be supplemented when it is due. Starting at the age of 35, estrogen levels gradually decline in women. With the onset of menopause (mostly above the age of 50), menopausal syndrome manifestations such as hot flashes, excessive sweating, and loss of emotional control become increasingly prominent. In addition, the chances of coronary heart disease, genital atrophy, and fractures increase significantly in perimenopausal women due to the decline in estrogen levels. According to statistics, ten years after menopause, 50% die of coronary heart disease and 30% die of complications two years after fracture. Therefore, giving estrogen supplements to women with significant symptoms during this phase becomes an important preventive measure for women’s health. The window of prevention for menopause is divided into three stages: first, the menopausal transition (40 to menopause); second, 45 to 55 years of age; and third, within 10 years of menopause. Experts point out that the early symptoms of estrogen deficiency are excessive sweating, hot flashes, insomnia and large fluctuations in blood pressure; the middle symptoms are body atrophy, dry skin and vaginal atrophy; and the late symptoms are osteoporosis. Proper estrogen supplementation during these three stages can reduce the incidence of other diseases. Numerous studies have shown that women who receive estrogen therapy during early menopause or perimenopause can significantly improve menopausal symptoms, increase sexual desire, reduce the incidence of fractures, and improve cardiovascular and cognitive function. However, estrogen therapy is a “double-edged sword” that can benefit those who use it well and harm those who abuse it. Women with a family history of breast cancer, unexplained vaginal bleeding, abnormal liver and kidney function, uterine fibroids, hypertension, diabetes, cerebral thrombosis within six months, etc. should be careful with estrogen supplementation. Tips: Before taking hormone supplements, it is necessary to assess the body’s suitability or need for estrogen supplementation, and to have breast, blood lipid, liver and kidney function, endometrial thickness and female endocrine examinations under the guidance of a doctor, and estrogen therapy should be carried out only after consulting a professional gynecologist.