As of current findings, the etiology of Parkinson’s disease remains unclear. Current research favors a combination of factors related to aging, genetic susceptibility, and exposure to environmental toxins. The first is ageing, the second is environmental factors, epidemiological findings found that there are regional differences in the prevalence of Parkinson’s disease, so there will be doctors who suspect that there may be some toxic substances in the environment that damage the neurons of the brain; the third is familial heritability, medical doctors have found in their long practice that Parkinson’s disease seems to have a tendency to gather in families, and families with Parkinson’s disease have a higher incidence of their relatives than Finally, there is a genetic predisposition to Parkinson’s disease. Although Parkinson’s disease is associated with aging and environmental toxins, not all older adults or people exposed to the same environment. Although there is also familial clustering in Parkinson’s disease, no clear causative gene has been found in disseminated Parkinson’s disease patients to date, indicating that the etiology of Parkinson’s disease is multifactorial. Therefore, no single factor can fully explain the etiology of Parkinson’s disease. Most researchers prefer that the etiology of Parkinson’s disease is the result of a combination of the above-mentioned factors. That is, after middle age, individuals who are susceptible to environmental toxins develop subclinical nigrostriatal damage after exposure to toxins due to their detoxification dysfunction, which worsens with age, and dopaminergic neurons progressively continue to die and degenerate, eventually losing compensation and developing clinical symptoms of Parkinson’s disease.