The etiology of Parkinson’s disease is unclear, with the incidence and prevalence of the disease slightly higher in men than in women, and the reasons for this are unclear. The onset of Parkinson’s disease is associated with ageing, environmental factors and genetics. Ageing is the main risk factor for Parkinson’s disease, with age, the nigrostriatal dopaminergic neurons show degenerative changes, about 6.9% of the nigrostriatal dopaminergic neurons die every 10 years after the age of 35, when more than 50% of the dopaminergic neurons die, the symptoms of Parkinson’s disease can appear, so Parkinson’s disease mainly occurs in middle-aged and elderly people over 50 years old, striatal dopamine transmitter content Decrease in striatal dopamine transmitter content by more than 80% before clinical symptoms of PD are manifested. Environmental factors: related to industrial toxins and exposure to pesticides and herbicides. Genetic factors: Only 10% have familial Parkinson’s disease, which is related to race and genetic factors.