Gray nails, also known as onychomycosis, need to be treated according to the patient’s specific condition, the reasonable use of drugs, surgery and physical methods, the appropriate treatment is the best. 1. Drugs: divided into local drugs and systemic drugs. (1) local drugs: such as amorolfine, etc., with broad-spectrum antifungal activity, the most sensitive to dermatophytes. 5% of amorolfine can be applied to the nail plate to form a layer of film that can not be dissolved in water, can quickly penetrate into the nail bed, but a small number of patients can appear burning sensation, itching and redness and other uncomfortable symptoms. Cyclopiazide can also be used, on the skin ringworm and yeast and other strong antibacterial and bactericidal effect, but some patients are prone to local skin irritation symptoms. (2) Systemic drugs: common such as terbinafine, belongs to the broad-spectrum antifungal drugs, has strong bactericidal effect on dermatophytes and yeasts, etc., some patients may have nausea, abdominal distension, etc.; itraconazole can also be used in the treatment of the disease, which is a broad-spectrum antifungal drug, need to closely monitor the liver function during the taking of the drug, and those who have abnormalities of the liver function should be used in accordance with the instructions of the doctor. 2. Surgery: For some gray nails, there is a single distal nail plate involvement and macular streak nail, but also need to carry out nail extraction or nail removal surgery for treatment. 3. Physical: such as laser treatment, with high targeting and high energy, has a certain inhibitory effect on the pathogenic bacteria; photodynamic therapy, is the use of photosensitizer combined with a certain wavelength of red light irradiation, to achieve the therapeutic purpose. Nail fungus treatment method is more, according to the patient’s specific condition to choose the appropriate method of treatment.