The difference between anogenital acne and anal fistula lies in the etiology, secretion and symptoms; acne is sebaceous cyst. 1. Etiology: anal sebaceous cysts in most cases is due to sebaceous gland duct blockage, so that sebaceous glands gradually stagnant, the formation of retention cysts; anal fistula is due to the abscess around the anorectum appeared to ulcerate or incision drainage lesions formed by granulomatous tube. 2. secretion: anal sebaceous cysts are unable to secrete; while anal fistula may secrete yellow liquid and fecal secretions, and accompanied by odor. 3. Symptoms: sebaceous cysts usually have no obvious symptoms, larger cysts may appear to compress the surrounding tissues, the phenomenon of suffocation; anal fistula will appear discharge, itching, pain, etc., may also be accompanied by fever, chills, general malaise and other uncomfortable symptoms. The anus appears on the chalk tumor or anal fistula, regardless of which disease once found, it is recommended to go to the hospital in a timely manner for examination, differential diagnosis, as soon as possible to carry out targeted treatment, to avoid delays in the condition.