Survival in advanced stages of hepatocellular carcinoma cannot be generalized and can only be roughly assessed by some research data. For example, studies have shown that the median survival period of hepatocellular carcinoma after diagnosis is 6 to 20 months. Hepatocellular carcinoma is the most common type of liver cancer, which has no obvious symptoms in the early stage, and once diagnosed, most of them are in the middle to late stage. There are also statistics showing that the median survival of symptomatic advanced hepatocellular carcinoma patients receiving systemic therapy is about 1-1.5 years. There are also some reports showing that if hepatocellular patients are left untreated after diagnosis, their median survival will be significantly shorter, typically 1 to 4 months. In addition, the survival period of hepatocellular carcinoma is not only related to the stage, but also the physical quality of the patient, treatment effect and other factors. If the physical quality is better and the treatment effect is better, then a longer survival period will be obtained. In conclusion, it is difficult to draw a definite conclusion on the survival period of advanced hepatocellular carcinoma, but following the doctor’s prescription, standardized treatment and keeping a good mindset can get a longer survival period and improve the quality of life of patients.