Tenofovir missed for a day does not usually require special remediation, as long as it is taken orally at the time of discovery. Because the terminal half-life of tenofovir is approximately 10 to 17 hours, 32% ± 10% of the administered dose is recovered in the urine within 24 hours after 300 mg is administered once or more times daily (in the fed state). It remains in the body for a long time. So if only missed a day of the body will still have some of the effect of the drug, will not lead to accelerated viral replication, missed a day of the general effect on the antiviral may not be particularly harmful, so found that this situation the next day to resume the normal regularity of the medication is good. However, if it occurs repeatedly, it may lead to some adverse reactions, especially the emergence of drug resistance or the rebound of the virus, which should be avoided. If the dose is missed for several days in a row or repeatedly missed, it may cause the virus to rebound and lead to the risk of liver injury or even liver failure. There is a great deal of individual variation in clinical practice, so it is important to go to the hospital in a timely manner in order to avoid delaying your condition.