Small blisters on the palms of the hands, i.e. small blisters, may be due to herpes sweat, contact dermatitis, tinea cruris blisters and other causes. 1. Sweat herpes: the occurrence of its disease may be related to mental factors, local infections, allergies and other reasons. Its lesions may be manifested as small hemispherical, rice-sized blisters deep in the skin of the hands, slightly above the skin, without redness around them. 2. Contact dermatitis: it may be an inflammatory reaction caused by contact with pollen, caterpillars, plastics and other foods on the hands. Its acute attack can be manifested as erythema, edema, which may be accompanied by papules, blisters, and oozing. 3. Blister ringworm: mainly caused by various fungal infections, including Trichophyton spp. and Microsporum spp. It occurs in the interphalangeal area and the palm. The skin lesions early for the needle tip size deep in the blisters, blister liquid clear, wall thick and shiny, not easy to break. Small blisters on the palm can also be seen in other diseases, it is recommended that patients go to the hospital in a timely manner, follow the doctor’s instructions for treatment, to avoid delaying the condition.