Pathological jaundice in newborns usually occurs early, and the degree of jaundice is relatively severe, which often requires treatment. There are many reasons for pathological jaundice, such as common neonatal infections, neonatal sepsis, urinary tract infections, etc. Some common ones are ABO hemolytic disease, and rare ones are Rh hemolytic disease, which can lead to pathological jaundice in newborns. In addition, due to the immaturity of neonatal liver and liver enzymes, it can lead to the reduction of bilirubin metabolism and elimination, and the jaundice lasts for a long time and is more severe, which also belongs to the pathological jaundice, and there is also a part of viral infections, for example, TORCH infections or inherited metabolic diseases, which can lead to jaundice aggravation, and the metabolism of the substrate can’t be discharged from the body due to the damage of multiple organs in a case where the child has a better milk intake. Jaundice aggravation, in short, the causes of neonatal pathologic jaundice are very complex and numerous.