The principle of treatment for gastrointestinal bleeding is to ensure the stability of vital signs, anti-shock treatment if necessary, and for gastrointestinal hemorrhage, the rapid replenishment of blood volume needs to be placed in the first place of all treatments. Gastrointestinal bleeding refers to bleeding in the gastrointestinal tract from the esophagus to the anus. Clinical manifestations depend on the amount of bleeding, bleeding rate, location and nature of bleeding, etc. When the symptoms are mild, there may not be any manifestations, but when the bleeding is obvious, it can be seen as blood in vomit, black stools, blood in the stools, and when it continues to aggravate, it can be accompanied by decreased blood volume or even shock. Upper gastrointestinal bleeding can use acid inhibitors such as esomeprazole, growth inhibitors, terlipressin and other vasoactive substances, but also the use of three-lumen two-bladder tube pressure hemostasis, endoscopic hemostasis, and if necessary, emergency surgery. Lower gastrointestinal bleeding, can use rectal embolization agent, injection of sclerosing agent and other hemorrhoid hemostasis; polyps feasible endoscopic resection; for vascular lesions can be endoscopic hemostasis, vascular intervention. When the bleeding is small, the patient should be kept in the head-high-feet-low lateral position and breathe freely, and oxygen should be inhaled when necessary, and fasting should be done during the bleeding activity period. When the bleeding volume is large, the patient’s vital signs should be closely detected, and once the circulating blood volume is insufficient, such as shock, the patient should immediately establish intravenous access, and infuse balanced salt solution to expand the volume, and if necessary, infuse suspended red blood cells to carry on the treatment. The patient should consult the doctor in time, make a clear diagnosis, and follow the doctor’s instructions for treatment.