The treatment for diffuse large B-cell lymphoma with total sweating includes general treatment, combined chemotherapy and so on. 1. General treatment: it is recommended to increase diet and nutrition, exercise appropriately, and when fever occurs, it can be treated with drugs such as arginine ibuprofen to reduce fever. 2. Combined chemotherapy: It is better to combine drugs for the cause of the disease, mainly including rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone and so on. Diffuse large B-cell lymphoma is the most common malignant non-Hodgkin’s lymphoma, characterized by diffuse infiltration of large B cells. Sweating is one of its clinical manifestations, along with painless lymph node enlargement in the neck and abdomen, fever, and weight loss. If the diagnosis of diffuse large B-cell lymphoma is confirmed, it is recommended to go to the hospital in a timely manner, under the guidance of the doctor for standardized treatment, the above drugs should not be taken on their own.