Whether urinary protein 2+ can develop into uremia needs to be judged by the combination of cause, condition and treatment effect. If it is physiological proteinuria, or the condition is mild, the treatment effect is good, usually will not develop into uremia; if it is pathologic proteinuria, and the condition is more serious, the treatment effect is not good, with the progress of the disease, may develop into uremia. Physiological proteinuria may be associated with strenuous exercise, fever, mental stress, change of body position, drug effects, etc., usually after their own habits or mindset adjustment can be improved, without special treatment, usually will not develop into uremia. Pathological proteinuria can be caused by a number of disease factors, such as primary glomerular disease, diabetic nephropathy, tubulointerstitial disease, etc. If the condition is mild and the treatment effect is good, it may not develop into uremia; if the condition is more serious and the treatment effect is not good, with the progress of the disease, it may develop into uremia. Urine protein 2 + may also have other causes, it is recommended that patients go to the regular hospital in a timely manner, improve the examination to clarify the cause of the disease, under the guidance of the doctor to target treatment or treatment.