Omeprazole and amoxicillin can treat H. pylori. If these two are used alone, they may not necessarily be cured, and need to be combined with other drugs for better eradication. At present, it is routinely recommended that a proton pump inhibitor + a bismuth + two antimicrobial drugs composed of quadruple therapy for the first-line treatment program, the course of treatment 10-14 days. 1. Proton pump inhibitors: such as omeprazole, rabeprazole, etc., can inhibit the secretion of gastric acid, providing good conditions for antibiotics to play antibacterial effects. Long-term application can lead to adverse reactions of vitamin B12 deficiency. Severe renal insufficiency, infants and young children, pregnant and lactating women are prohibited. 2. Bismuth agent: such as bismuth potassium citrate, bismuth pectin, etc. Under the action of gastric acid, bismuth salts and viscous condensate are formed and coated on the surface of the stomach, forming a protective layer and killing Helicobacter pylori directly. Because bismuth can be absorbed in small amounts, it is not suitable for long-term use, and it is generally appropriate to use the medicine for no more than 8 weeks. The color of stool will become black after taking the medicine, and will subside after stopping the medicine. 3. two antibiotics: such as clarithromycin, amoxicillin, metronidazole or tinidazole, levofloxacin, furazolidone, tetracycline, etc. Two of the antibiotics, should be based on the local drug-resistant specifics, the combination of antibiotics on the Helicobacter pylori bacteria have a powerful bactericidal effect. It can cause skin rash, allergy and other adverse reactions, pregnant women and breastfeeding women should be cautious, pay attention to monitor the liver and kidney function. After the diagnosis of Helicobacter pylori infection, it is recommended to consult the gastroenterology department in a timely manner, under the guidance of the doctor to follow the doctor’s instructions to take medication, to avoid unauthorized use of medication, delay the condition.