The side effects of a+c influenza conjugate vaccine are generally mild and last for 1~2 days for recovery. Epidemic cerebrospinal meningitis can be transmitted through the respiratory tract, with high mortality rate and many sequelae. Once the disease develops, it has a great impact on children’s body and development, which may lead to epilepsy, developmental effects or even fatal, therefore, it is recommended to actively carry out vaccination prevention. At present, there are many types of vaccines for influenza, and the better vaccination program for protection is to receive A+C conjugate vaccine at the age of 3, 4 and 5 months, and then 4-valent polysaccharide vaccine at the age of 3 and 6 years respectively. According to the instructions for use of A+C conjugate vaccine, adverse reactions include occasional transient fever, rash, dizziness, headache, malaise, loss of appetite, abdominal pain and diarrhea, as well as redness, swelling, and pain at the injection site, which can be relieved on their own. Clinical observation of A+C Influenza Conjugate Vaccine usually lasts for 1~2 days and can recover on its own, and medical treatment is recommended for severe cases. Epidemic cerebrospinal meningitis sequelae are serious, parents are advised to arrange for their children to be vaccinated in a timely manner, side effects are treated symptomatically, and timely medical treatment is necessary.