Blood creatinine 250μmol / L first need to improve the relevant examination, clear acute or chronic kidney disease, and then find the cause of the cause of treatment. For acute kidney injury, according to the cause of the symptomatic treatment, such as anti-infection, stopping damage-causing drugs, fluid replacement; chronic kidney disease patients, need to be given to reduce protein, control blood pressure and other treatments. 1. Acute kidney injury: patients need to be treated according to the specific causes, such as acute kidney injury caused by infection should be treated with corresponding antibiotics in time; if acute kidney injury is caused by medication, the medication should be stopped in time; if it is caused by excessive blood loss, it needs to be treated by replenishment of blood volume and other related treatments. 2. Chronic kidney disease: For patients with chronic kidney disease, they should reduce urinary protein, lower blood pressure and delay renal function and other treatments. You can choose valsartan, benadryl, renal failure capsule, urethane and other drugs. The above medication should follow the doctor’s instructions, not blindly use drugs to avoid a more serious condition. It should be noted that if the patient has abnormal blood creatinine, he should consult the regular hospital in time to find out the cause of the disease and actively treat it.