Acne on both sides of the face may be caused by physiological reasons such as exuberant secretion of androgens, or it may be caused by acne and milia. It can be treated with oral or topical medications, such as topical application of retinoic acid cream, oral loratadine and isotretinoin soft capsules under the guidance and advice of a doctor. 1. Excessive secretion of androgen: Excessive secretion of androgen after puberty leads to increased activity of sebaceous glands, increased oil secretion, keratinization of sebaceous ducts, and the formation of pimples on the cheeks, which can be treated with topical retinoic acid cream under the guidance of a doctor. 2. Acne: A large number of Propionibacterium acnes bacteria lead to pore clogging, thus causing the symptoms of pimples on both sides of the face, the patient can take isotretinoin soft capsule under the guidance of the doctor’s advice to carry on the treatment. 3. Corns: due to the excessive secretion of skin oil, can not be discharged in a timely manner, the accumulation of the formation of the subcutaneous, thus leading to the phenomenon of acne on both sides of the face. Loratadine can be taken under the guidance and advice of the doctor for treatment. When the patient appears on both sides of the face long acne, exclude physiological reasons, should consult a doctor in time, ask the doctor to clarify the cause of the disease, and under the guidance of the doctor to take medication, remember not to take it privately, so as to avoid adverse effects.