For newborns, jaundice is mainly categorized into physiological jaundice, breast milk jaundice and pathological jaundice. Physiological jaundice and breast milk jaundice are normal physiological reactions and generally do not affect BCG vaccination. Currently, the jaundice value of full-term infants should not exceed 10-12mg/dl, and that of preterm infants should not exceed 15mg/dl. If there is no progressively worsening jaundice symptoms and no clinical abnormality, physiological jaundice is most likely to be considered, and it is recommended to consider BCG vaccination when the jaundice value is lower than 8-10mg/dl, which is safer and will not cause any clinical side-effects. For pathologic jaundice, the value of jaundice will be significantly increased, and can even reach more than 20mg/dl, with the risk of bilirubin encephalopathy. Therefore, it is necessary to treat the primary disease in a timely manner, in some cases through medication and in others through surgery. Vaccines such as BCG should not be given until the jaundice is under control.