Hepatitis B surface antigen quantitative greater than 160, if the liver function is obviously abnormal, it means the disease is more serious, if the liver function is normal and there is no cirrhosis, it means hepatitis B is not serious. Hepatitis B surface antigen is greater than 160, indicating a high antigen titer, suggesting that there is hepatitis B virus infection, the specific level of the disease, need to be combined with other indicators to determine the overall. Hepatitis B surface antigen greater than 160, if the liver function is obviously abnormal, and the viral load is replicated in large quantities, it means that the virus is in the active replication period and has caused certain damage to the liver, which is more serious, and it needs active antiviral and liver-protecting treatment. If the quantitative hepatitis B surface antigen is greater than 160, but the DNA replication is relatively stable, the liver function is not damaged, and there is no cirrhosis, it suggests that the disease is not serious, and the disease should be monitored by regular review.