Professor Zammit (Cardiff University, UK) and his colleagues said: “Infection during pregnancy is strongly associated with an increased risk of schizophrenia in mothers and their children. This may be related to the use of analgesic medication during pregnancy, which reduces the symptoms of viral infection. This may partially explain the association between maternal infection and increased risk of schizophrenia in children.” The study included 6,437 children and their mothers. There were 3,901 mothers who had taken analgesic drugs during pregnancy, including 3,758 (58.4%) who had taken paracetamol, 345 (5.7%) who had taken aspirin, and 209 (3.2%) who had taken other types of analgesic drugs. In addition, 398 cases (6.2%) had taken more than one analgesic drug. A semi-structured interview was used to investigate children up to 12 years of age, which showed that 880 cases (13.6%) were suspected of having or clearly having psychotic symptoms, of which 409 (46%) were boys and 471 were girls. After correcting for maternal history of smoking, depressive disorders, family history of psychiatric disorders, age, infections, and use of other non-analgesic medications, the researchers found that maternal aspirin use during pregnancy increased the risk of psychotic symptoms in children (12 years old) by 1.44 times compared to subjects who had not taken analgesic medications. At the same time, mothers taking long-term aspirin medication had a significantly increased risk of concomitant psychiatric disorders in their offspring. The risk was increased 2.79 times compared to mothers who did not take analgesic drugs. In addition, the study noted that, after correcting for confounding factors, taking acetaminophen (paracetamol) or other types of analgesic drugs during pregnancy did not increase the risk of concomitant psychiatric symptoms in the children. Finally, Professor Zammit and his team concluded that the use of aspirin during pregnancy can interfere with prostaglandin pathways, which may increase the risk of schizophrenia in their children. However, we still need a lot of research to confirm this conclusion.