A positive TRUST is usually a non-specific syphilis antibody test, also known as a positive syphilis toluidine red non-heating serologic test, indicating a current or previous history of infection with the syphilis spirochete. In the absence of treatment, the patient is now more likely to be infected with syphilis, at which point a TPPA antibody test is required. If the TPPA antibody test is also positive, the diagnosis of syphilis infection is usually confirmed. If the patient is only TRUST positive, it does not indicate syphilis and has no clear relationship to the severity of the disease. For example, in patients with latent syphilis, although TRUST is positive, there are no other symptoms. Patients with severe neurosyphilis and cardiovascular syphilis, on the other hand, can be negative for TRUST, although they are more severely ill at this time. In addition, some patients with connective tissue diseases and infectious diseases, such as lupus erythematosus and rheumatoid arthritis, may even have a false-positive TRUST test. Therefore, patients need to have a TRUST test followed by a rapid plasma reactin test, i.e. syphilis titer, before the diagnosis of the relevant disease can be confirmed. If syphilis is diagnosed, it is important to aggressively treat the syphilis, usually with penicillin as the first choice, and the general choice is benzathine penicillin. If the patient is allergic to penicillin, cephalosporin antibiotics, such as ceftriaxone sodium, can be chosen for treatment. The length of treatment depends on the severity of the syphilis, and the degree of early and late.