Uremia can cause headaches, the more common causes are renal hypertension, uremic encephalopathy and so on. 1. Uremia can lead to renal hypertension, hypertension is more serious patients can appear headache symptoms, which is the most common cause of headache in patients with uremia. 2. Uremic patients can not excrete a variety of metabolic wastes and decomposition of various hormones or peptides, these substances across the blood-brain barrier, accumulation in the brain can cause uremic encephalopathy, thus causing headaches. 3. Uremic patients are prone to cerebral infarction, cerebral hemorrhage and other complications, which can also cause headaches. 4. Uremic patients who have just begun hemodialysis can develop dialysis imbalance syndrome, which can be manifested as headache, due to the faster reduction of toxins, causing brain cell edema. Uremia can lead to headaches, but there are many other causes can lead to headaches, such as vascular headaches, migraines, etc., the patient needs to be diagnosed in the regular hospital to improve the relevant examination, diagnosis and treatment of the cause.