Orlistat and B vitamins are not recommended to be taken at the same time and should be spaced 2 hours apart, both are used for weight control while replenishing the body’s vitamin needs in a timely manner. Orlistat is a gastrointestinal lipase inhibitor, which reduces calorie intake, weight control, and can easily cause a decrease in vitamin absorption. Therefore, it is important to take Orlistat with timely vitamin supplementation so as not to make the patient increase the chances of convulsions, spasms, and so on. Orlistat and vitamin B should not be taken at the same time, it is recommended to choose to supplement vitamin B 2 hours after taking Orlistat, so as not to affect the effect of vitamins. The above medications should be used under the supervision of a medical professional. Orlistat and Vitamin B should be taken in accordance with medical advice, and the occurrence of uncomfortable symptoms in a timely manner to consult a doctor.