A very hard pimple on the left cheek, which hurts when pressed, may be related to folliculitis, skin boils, acne, etc. In terms of treatment, medication is mainly given. 1. Folliculitis is caused by damaged hair follicles infected with bacteria and other pathogens. The main treatment is to give targeted treatment, such as caused by bacterial infection, you can use topical antibiotics such as mupirocin ointment, clindamycin ointment and so on. 2. Skin boil is an acute inflammation that occurs deep in the hair follicle, initially appearing as a small lump under the skin with pressure and pain, and later may appear obvious redness and swelling. In terms of treatment, it is usually given anti-infective treatment, such as oral capsule of Roxithromycin, topical ichthyol ointment and so on. 3. Acne is a chronic inflammatory skin disease that is usually not particularly painful. When the infection is further aggravated by excessive squeezing and irritation, pustular acne may occur, showing localized pain, and can be treated with a combination of topical erythromycin isotretinoin ointment, oral doxycycline tablets and other medications. Due to the obvious individual differences in treatment effects, the specific situation needs to be consulted by a doctor before following the doctor’s prescription medication, do not self-medication.