There are two main causes of high platelet pressure product. First, the total increase in platelets, the total number of platelets is elevated, such as infection, blood loss, hemolysis, tumors can make platelets elevated, too high, in the case of excluding other blood disease systems, the cause of thrombocytosis must be identified, such as the primary or secondary platelet elevation. The second important reason for high platelet pressure is the increase in the average volume of platelets. The increase in the average volume of platelets indicates a high degree of maturation of megakaryocytes and good bone marrow platelet production. When the blood vessel is damaged and contracted, the platelet glycoprotein on its own surface adheres to the collagen under the endothelium, and the platelet aggregates with each other, resulting in the accumulation of platelets, which naturally increases the pressure level.